Pablo Hervella

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+45 65 508 432
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Pablo Hervella qualified with a PhD. Degree in Physical Chemistry from the University of Santiago de Compostela, Santiago de Compostela (Spain) with a thesis entitled “Reactivity in polymeric micelles and microemulsions”. During his Postoctoral training at the Swiss Institute of Technology ETH, (Switzerland), and in the School of Pharmacy, University of Santiago de Compostela, Pablo's research was focused on the development of nanoparticles for the in vivo labelling of tumor cells, and on the encapsulation of antitumor drugs in nanoparticulate drug delivery systems. Specifically he has been interested in the development of fluorescent nanoparticles for the in vivo imaging of metastatic cells present in the lymphatic system. Research included the synthesis and characterization of nanoparticles aimed to target metastatic cells, in vitro cell uptake in several cell lines, analysis by Flow cytometry (FACS) and by microscopy.   Also, he designed new drug delivery systems for cancer treatment. This project was part of a collaboration with two pharmaceutical companies (PharmaMar S.A. and FAES FARMA S.A.) aimed to formulate poorly soluble drugs intended for oral and parenteral administration. New self-emulsifying drug delivery systems (SEDDS), nanocapsules and nanoparticles were developed. Since 2013, Pablo has been working in the Centre for Single Particle Science and Engineering (SPSE). His interest are the visualization of nanoparticle uptake in tumors by PET imaging, cellular uptake of fluorescent nanoparticles, formulation and in vitro evaluation of anticancer drugs and siRNA.

Publications

1.      David Needham, Amina Arslanagic, Kasper Glud, Pablo Hervella, Leena Karimi, Poul Flemming Høilund-Carlsen, Koji Kinoshita, Jan Mollenhauer, Elisa Parra, Anders Utoft, and Prasad Walke,  (2016)Bottom Up Design of Nanoparticles (to eventually treat cancer): “Put the drug in the Cancer’s food”, J. Drug Targeting  2016, accepted, in press

2.      Jinsoo Yi, Tine A Knudsen, Anne-Louise Nielsen, Lars Duelund, Morten Christensen, Pablo Hervella, David Needham, Ole G Mouritsen, (2016). Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols,  Chem.Phys.Lipids 200, 62–73

3.      Athanasia Dasargyri, Pablo Hervella, Ailsa Christiansen, Steven Proulx, Michael Detmar, Jean-Christophe Leroux “Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles”. Journal of Controlled Release (2016), 22, 229-238. 

4.      Pablo Hervella2, Elisa Parra and David Needham. “Encapsulation and retention of chelated-Copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation” Accepted in European Journal of Pharmaceutics and Biopharmaceutics  (2016), 102, 64-76.

5.       Giovanna Lollo, Pablo Hervella, Pilar Calvo, Pablo Avilés,  M.J.Guillén, Marcos Garcia-Fuentes, Dolores Torres, Maria José Alonso “Enhanced in vivo therapeutic efficacy of plitidepsin-loaded nanocapsules decorated with a new poly-aminoacid-PEG derivative” International Journal of Pharmaceutics  (2015).  483, 1-2, 212-219. 

6.      P. Hervella, M. Alonso-Sande, F. Ledo, M.L. Lucero, M.J. Alonso, M. Garcia-Fuentes. “Pegylated lipid nanocapsules with improved drug encapsulation and controlled release properties” Current Topics in Medicinal Chemistry  (2014), 14, 9, 1115-1123. 

7.      A. Pratsinis, P. Hervella, J.C. Leroux, S. E. Pratsinis, G. A. Sotiriou. “Toxicity of silver nanoparticles in macrophages” Small  (2013). 9,15, 2576-2584. 

8.      P.Hervella, V. Lozano, M. Garcia-Fuentes, M.J. Alonso. “Nanomedicine: New challenges and opportunities in cancer therapy” Journal of Biomedical Nanotechnology  (2008) ,3, 276-292. 

9.      Ledo, F; Hervella, P, Alonso-Sande, M , Garcia-Fuentes, M , Lucero, ML , Alonso, MJ. “PEG-coated nanoemulsions, a carrier of pharmaceutical interest for the delivery of antitumoral drugs” Methods and findings in experimental and clinical pharmacology.  (2008), 30,2, 123-123

10.   G. Astray, A. Cid, L. Garcia-Rio, P. Hervella, J. C. Mejuto, M. Perez-Lorenzo. “Organic reactivity in AOT-stabilized microemulsions” Progress in Reaction Kinetics and Mechanism  (2008), 33, 81-97. 

11.   Cabaleiro Lago, L. Garcia-Rio, P. Hervella1 “The effect of changing the microstructure of a microemulsion on chemical reactivity”. Langmuir  (2007), 23, 9586-9595.

12.   L. García-Río, P. Hervella1 “Application of the pseudophase ion-exchange model to reactivity in quaternary water in oil microemulsions”.   New Journal of Chemistry, (2007), 31, 860-870. 

13.   L.Garcia-Rio, P.Hervella1 J. C. Mejuto, M.  Parajo “Spectroscopic and kinetic investigation of the interaction between  crystal violet and sodium dodecyl sulfate”. Chemical Physics(2007), 335, 164-176.

14.   L.García-Río, P. Hervella1 “Kinetic Model for Reactivity in Quaternary Water-in-Oil Microemulsions”. Chemistry - A European Journal  .(2006),12,. 8284-8295. 

15.   L.García-Río, P. Hervella1, P. Rodríguez-Dafonte “Solvolysis of Benzoyl Halides in Water/NH4DEHP/Isooctane Microemulsions”. Langmuir; (2006); 22, 7499 – 7506. 

16.   L.García-Río, P. Hervella1, J. R. Leis “Ionizing Power and Nucleophilicity in Water in Oil AOT-Based Microemulsions”. Langmuir (2005); 21, 7672 – 7679. 

Book Chapters

17.   P. Hervella, G. Lollo, F. Oyarzun-Ampuero, G. Rivera, D. Torres, M. J. Alonso. “Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules” Nanocomposite Particles for Bio-Applications - Materials and Bio-Interfaces (2011), 45-69.