SPSE  publications

  1. Birgitte Brinkmann Olsen, Helge Thisgaard, Stefan Vogel, Mads Thomassen, Torben A. Kruse, David Needham, Jan Mollenhauer and Poul Flemming Høilund-Carlsen, (2013) Novel Radioisotope-Based Nanomedical Approaches, European Journal of Nanomedicine. Volume 5, Issue 4, Pages 181–193, ISSN (Online) 1662-596X, ISSN (Print) 1662-5986, (PR) (Open Access) Journal :

  2. Luis A. Bagatolli and David Needham, (2014).  Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles, Chemistry and Physics of Lipids 181, 99–120. Epub 2014 Mar 13 (PR)  (Not Open Access) Journal:

  3. Joachim Habel, Anayo Ogbonna, Nanna Larsen, Sol`ene Cherr´e, Søren Kynde, Søren Roi Midtgaard, Koji Kinoshita, Simon Krabbe, Grethe Vestergaard Jensen, Jesper Søndergaard Hansen, Kristoffer Almdal and Claus H`elix-Nielsen, (2015). Selecting analytical tools for characterization of polymersomes in aqueous solution, RSC Adv., 5, 79924-79946.!divAbstract

  4. Pablo Hervella, Elisa Parra, David Needham, Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation, Eur, J. Phar. Biophar., 2016, 102, 64-76,

  5. Jinsoo Yi, Tine A Knudsen, Anne-Louise Nielsen, Lars Duelund, Morten Christensen, Pablo Hervella, David Needham, Ole G Mouritsen, (2016). Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols,  Chem.Phys.Lipids 200, 62–73,

  6. David Needham, Amina Arslanagic, Kasper Glud, Pablo Hervella, Leena Karimi, Poul Flemming Høilund-Carlsen, Koji Kinoshita, Jan Mollenhauer, Elisa Parra, Anders Utoft, and Prasad Walke, Bottom up design of nanoparticles for anti-cancer diapeutics: “put the drug in the cancer’s food”, invited paper, Special issue of J. Drug Targeting in honor of Pieter Cullis, Life-time Achievement Award for 2016,

  7. Elisa Parra, Koji Kinoshita and David Needham, Micropipette Technique Study of Natural and Synthetic Lung Surfactants at the Air−Water Interface: Presence of a SP‑B Analog Peptide Promotes Membrane Aggregation, Formation of Tightly Stacked Lamellae, and Growth of Myelin Figures, Langmuir 32 (2016) 10570-10581, DOI: 10.1021/acs.langmuir.6b01420,

  8. Koji Kinoshita, Elisa Parra, Abdirazak Hussein, Anders Utoft, Prasad Walke, Robin de Bruijn and David Needham, From Single Microparticles to Microfluidic Emulsification: Fundamental Properties (Solubility, Density, Phase Separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres, Processes, 4 (2016) 49; doi:10.3390/pr4040049,

  9. Deborah Bitterfield, Anders Utoft, and David Needham, An Activity-Based Dissolution Model for Solute-Containing Microdroplets, Langmuir 32 (2016) 48, 12749-12759, DOI: 10.1021/acs.langmuir.6b03126,

  10. David Needham, Bringing Research to Clinical Application: Lessons from Thermodox - A Thermal Sensitive Liposome for Treatment of Cancer”, invited chapter, In " Drug Delivery: Fundamentals and Applications, Editors, HILLERY, AM, SWARBRICK J, PARK, K.  CRC press (2017) Taylor & Francis group, New York

  11. Koji Kinoshita, Elisa Parra, and David Needham, New Sensitive Micro-Measurements of Dynamic Surface Tension and Diffusion Coefficients: Validated and Tested for the Adsorption of 1-Octanol at a Microscopic Air-Water Interface and its Dissolution into Water, J. Colloid and Interface Science, 488 (2017) 166-179,

  12. Elisa Parra, Pablo Hervella and David Needham, Real-Time Visualization of the Precipitation and Phase Behavior of Octaethylporphyrin in Lipid Microparticles , J. Pharmaceutics Sci. 106 (2017) 1025-1041,

  13. Elisa Parra and David Needham, (2017) Mechanic assays based on micropipette aspiration", in "The Giant Vesicle Book", invited chapter, edited by Carlos Marques and Rumiana Dimova, CRC Press – Taylor & Francis in 2016, accepted, in press

  14. Koji Kinoshita, Elisa Parra, and David Needham. (2017) Adsorption of ionic surfactants at microscopic air-water interfaces using the micropipette interfacial area-expansion method: Measurement of the diffusion coefficient and renormalization of the mean ionic activity for SDS. J Colloid Interface Sci. 2017 May 25;504:765-779. doi: 10.1016/j.jcis.2017.05.077. [Epub ahead of print]

Earlier publication by Needham and collaborators, on which the SPSE center is based

Microparticle and Interfacial Studies

  • S. Lee, D. H. Kim, and D. Needham.  (2001) Static and Dynamic Surface Tension Measurement of Microscopic Interfaces Using a Micropipet Technique: 1.  A New Method for Determination of Surface Tension, Langmuir 2001, 17, 5537-5543. 

  • S. Lee, D. H. Kim, and D. Needham.  (2001) Static and Dynamic Surface Tension Measurement of Microscopic Interfaces Using a Micropipet Technique: 2.  Dynamics of Phospholipid Monolyer Formation and Equilibrium Spreading Pressures at the Air-Water Interface, Langmuir 2001, 17, 5544-5550

  • D. H. Kim, M, J. Costello, P. B. Duncan and D. Needham, (2003).  Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells - novel solid nanoparticles, Langmuir, 19, 8455-8466

  • P. Duncan and D. Needham, (2004).  Test of the Epstein-Plesset Model for Gas Microparticle Dissolution in Aqueous Media: Effect of Surface Tension and Gas Undersaturation in Solution. Langmuir; 20(7); 2567-2578.

  • P. Duncan and D. Needham, Microdroplet dissolution into a second-phase solvent using a micropipet technique: Test of the Epstein-Plesset model for an aniline-water system  (2006), Langmuir, 22   Issue: 9   Pages: 4190-4197     

  • S. I. Simon, K. Florine-Casteel, K. Ritchie, H.P. Ting-Beall, E. Evans, and D. Needham, (2007).  Dynamics of Neutrophil Membrane Compliance and Microstructure probed with a Micropipet-based  Piconewton Force Transducer, Annals Biomed Egr. Volume 35, Number 4 / April, 2007, 595-604

  • M.  Holden, D. Needham, H Bayley, (2007). Functional Bio-Networks from Nanoliter Water Droplets J. Am Chem Soc., vol. 129, pp. 8650-8655

  • Chiming Yang, David Plackett, David Needham , Helen M. Burt (2009) PLGA and PHBV microsphere formulations and solid-state characterization: Local delivery of fusidic acid for the treatment and prevention of orthopaedic infections, Pharmaceutical Research, Vol. 26, No. 7.

  • Jonathan T Su, David Needham, (2010) The Effects of Hydrogen Bonding on the Diffusion of Water in n-Alkanes and n-Alcohols Measured with a Novel Single Microdroplet Method, J. Chem Phys Volume: 132 Issue: 4 Page: 044506, 

  • Deborah L Rickard, Brent Duncan and David Needham, (2010). Hydration Potential of Lysozyme: Protein Dehydration Using a Single Microparticle Technique, Biophysical Journal, Volume 98, Issue 6, 17 March 2010, Pages 1075-1084 

  • David Needham, (2011).  Lipid structures: A brief history of multisomes, Nature Nanotechnology , News and Views 6, 761–762, Published online, 06 December 2011.

  • Samuel E. Gilchrist, Deborah L. Rickard, Kevin Letchford, David Needham & Helen M. Burt (2012). The phase separation behavior of fusidic acid and rifampicin in PLGA microspheres, published on line,  Molecular Pharmaceutics. DOI: 10.1021/mp300099f • Publication Date (Web): 07 Apr 2012.

  • David Needham, (2012). Micropipette Manipulation of Lipid Bilayer Membranes, Encyclopedia of Biophysics, Springer

Drug Delivery Publications (Thermo Sensitive Liposome)

  • Yarmolenko PS, Zhao Y, Landon C, Spasojevic I, Yuan F, Needham D, Viglianti BL, Dewhirst MW. (2010). Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumors. Int J Hyperthermia. 2010;26(5):485-98. Times Cited: 16

  • Grant, GA, Wilson, C, Salami, S,  Macaroni, P, Li, SQ, Park, JY, Needham, D, Bigner, D Dewhirst, MW., PRECLINICAL USE OF MILD HYPERTHERMIA TO ENHANCE DRUG DELIVERY TO BRAIN TUMORs, NEURO-ONCOLOGY  Volume: 13   Supplement: 3   Pages: 111-111: NOV 2011

  • C. Landon, J.Y. Park, D. Needham, and M. W. Dewhirst, (2011). Nano-Encapsulation Technology for Drug Delivery, in "Therapeutic Approaches and Drug Delivery", The Open Nanomedicine Journal, 2011, 3, 38-64, Wiley Interdisciplinary Reviews: Nanomedicine & Nanobiotechnology, John Wiley & Sons, Inc. 

  • D. Needham and M. W. Dewhirst, (2012), Materials Science and Engineering of the Low Temperature Sensitive Liposome (LTSL): Composition-Structure-Property Relationships that Underlie its Design and Performance, (Chapter 2).  In “Smart Materials for Drug Delivery”, Carmen Alvarez-Lorenzo and Angel Concheiro Eds, Royal Society of Chemistry, Publishing.

  • Ashley A. Manzoor, Lars H. Lindner, Ji-Young Park, Andrew J. Simnick, Matthew R. Dreher, Shiva Das, Gabi Hanna, Won Park, Gerben Koning, Timo ten Hagen, David Needham, Mark W. Dewhirst, (2012).  Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors, Cancer Research doi:10.1158/0008-5472.CAN-12-1683.

  • Ryan M Davis, Benjamin L Viglianti, Pavel Yarmolenko, Paul Stauffer, Ji-Young Park, Paolo Maccarini, David Needham, Mark W Dewhirst(2012).  Simultaneously monitoring tumor temperature and temperature sensitive liposome content release with MRI, in review Int.  J. Hyperthermia

  • David Needham, Ji-Young Park, Alexander M. Wright, Jihong Tong (2012).  Materials Characterization of the Low Temperature Sensitive Liposome (LTSL): Effects of Lipid Composition (Lysolipid and DSPE-PEG2000) on the Thermal Transition and Release of Doxorubicin.  Faraday Discussions Faraday Discussion 161: Lipids and Membrane Biophysics Accepted manuscript, DOI: 10.1039/C2FD20111A